During a four-level pressure cuff assessment, which lesion does NOT cause abnormally low high-thigh pressure?

In a four-level pressure cuff assessment, high-thigh pressure is primarily influenced by blood flow through the common femoral artery and its branches. An isolated disease affecting the profunda femoral artery, or deep femoral artery, typically does not result in low high-thigh pressure because this artery primarily supplies blood to the deep structures of the thigh.

When there is isolated profunda femoral artery disease, the common femoral artery remains patent and can still provide adequate blood flow, thereby maintaining normal or near-normal high-thigh pressures. In contrast, lesions like aortoiliac obstruction, superficial femoral artery disease, or common femoral artery disease block the flow of blood in a way that can significantly reduce pressures measured at the high-thigh level.

Thus, the absence of low high-thigh pressure in the context of isolated profunda femoral artery disease makes it the correct choice.